Methotrexate (methotrexate): Reviews and patient testimonials

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Medication indications

Methotrexate 10 mg Tablets

• Severe forms of psoriasis vulgaris, particularly of the plaque type, which cannot be sufficiently treated with conventional therapy such as phototherapy and PUVA, and severe psoriatic arthritis.

• Active rheumatoid arthritis in adult patients.

Methotrexate 100 mg/ml concentrate for solution for infusion

Acute lymphocytic leukaemia, Non-Hodgkin's lymphomas, osteogenic sarcoma, adjuvant and in advance disease of breast cancer, metastatic or recurrent head and neck cancer, choriocarcinoma and similar trophoblastic diseases, advanced cancer of urinary bladder.

Methotrexate 100 mg/ml Injection

Methotrexate is indicated in the treatment of neoplastic disease, such as trophoblastic neoplasms and leukaemia, and the symptomatic treatment of severe recalcitrant disabling psoriasis which is not adequately responsive to other forms of therapy.

Methotrexate 100 mg/ml solution for injection

Methotrexate 100 mg/ml solution for injection may be used for the following indications:

• Acute lymphocytic leukaemias (ALL)

- in combination with other cytotoxic medicinal products

• Non-Hodgkin's lymphomas

- in combination with other cytotoxic medicinal products in adult patients with Non-Hodgkin's lymphomas of intermediate and high degree of malignancy

- -in combination with other cytotoxic medicinal products in paediatric patients

• Head and neck cancer

- as palliative monotherapy in patients with metastatic or recurrent disease

• Breast cancer

- in combination with other cytotoxic medicinal products in patients for adjuvant treatment after tumour resection or mastectomy and for palliative treatment in advanced disease

• Choriocarcinoma and similar trophoblastic diseases

- as monotherapy in patients with good prognosis (low risk)

- in combination with other cytotoxic medicinal products in patients with poor prognosis (high risk)

• Osteosarcoma

- in combination with other cytotoxic medicinal products for adjuvant and neoadjuvant therapy

• Cancer of the bladder

- in combination with other cytotoxic medicinal products

Methotrexate 10mg tablets

- Active rheumatoid arthritis in adult patients.

- Severe recalcitrant disabling psoriasis, which is not adequately responsive to other forms of therapy such as phototherapy, PUVA, and retinoids, and severe psoriatic arthritis in adult patients

Methotrexate 10mg Tablets BP

The treatment of acute lymphoblastic leukaemia and Burkitt's lymphoma. The treatment of severe cases of uncontrolled psoriasis, unresponsive to conventional therapy.

Methotrexate 2.5 mg Tablets

• Severe forms of psoriasis vulgaris, particularly of the plaque type, which cannot be sufficiently treated with conventional therapy such as phototherapy and PUVA, and severe psoriatic arthritis.

• Active rheumatoid arthritis in adult patients.

Methotrexate 2.5 mg/ml Injection

Methotrexate is indicated in the treatment of neoplastic disease, such as trophoblastic neoplasms and leukaemia, and the symptomatic treatment of severe recalcitrant disabling psoriasis which is not adequately responsive to other forms of therapy.

Methotrexate 2.5mg Tablets

Methotrexate is a folic acid antagonist and is classified as an antimetabolite cytotoxic agent.

Methotrexate has been used to produce regression in a wide range of neoplastic conditions including acute leukaemias, non-Hodgkin's lymphoma, soft-tissue and osteogenic sarcomas, and solid tumours particularly breast, lung, head and neck, bladder, cervical, ovarian, and testicular carcinoma.

The treatment of neoplastic disease. Methotrexate has also been used in the treatment of severe cases of uncontrolled psoriasis, unresponsive to conventional therapy.

It is also used in the treatment of adults with severe, active, classical or definite rheumatoid arthritis who are unresponsive or intolerant to conventional therapy.

Methotrexate 2.5mg tablets

- Active rheumatoid arthritis in adult patients.

- Severe recalcitrant disabling psoriasis, which is not adequately responsive to other forms of therapy such as phototherapy, PUVA, and retinoids, and severe psoriatic arthritis in adult patients

Methotrexate 2.5mg Tablets BP

The treatment of acute lymphoblastic leukaemia and Burkitt's lymphoma. The treatment of severe cases of uncontrolled psoriasis, unresponsive to conventional therapy.

The treatment of adults with severe, active, classical or definite rheumatoid arthritis who are unresponsive or intolerant to conventional therapy.

Methotrexate 25 mg/ml Injection

Methotrexate is indicated in the treatment of neoplastic disease, such as trophoblastic neoplasms and leukaemia, and the symptomatic treatment of severe recalcitrant disabling psoriasis which is not adequately responsive to other forms of therapy.

Methotrexate 25 mg/ml solution for injection

Acute lymphocytic leukaemia, prophylaxis of meningeal leukaemia, Non-Hodgkin's lymphomas, osteogenic sarcoma, adjuvant and in advance disease of breast cancer, metastatic or recurrent head and neck cancer, choriocarcinoma and similar trophoblastic diseases, advanced cancer of urinary bladder.

Methotrexate 25 mg/ml solution for injection, pre-filled syringe

- Active rheumatoid arthritis in adult patients where treatment with disease modifying antirheumatic drugs (DMARD) is indicated.

- Polyarthritic forms of severe, active juvenile idiopathic arthritis (JIA), when the response to non-steroidal anti-inflammatory drugs (NSAIDs) has been inadequate.

- Severe forms of psoriasis vulgaris, particularly of the plaque type, which cannot be sufficiently treated with conventional therapy such as phototherapy, PUVA, and retinoids, and severe psoriatic arthritis.

Methotrexate 2mg/ml Oral Solution

Methotrexate 2mg/ml Oral Solution is indicated in the following oncological indications:

• The maintenance treatment of Acute Lymphocytic Leukaemia (ALL) in children and adults.

• The treatment of malignant trophoblastic tumours

Methotrexate 2mg/ml Oral Solution is indicated in:

• The treatment of severe active rheumatoid arthritis in adults.

• The treatment of severe forms of psoriasis vulgaris including chronic plaque psoriasis, erythrodermic psoriasis, psoriatic arthritis and pustular psoriasis which are not responsive to other conventional therapies such as phototherapy, PUVA and retinoids.


Route of administration: Injectable, Oral
Molecule: methotrexate

The opinion of 19 patients on Methotrexate

In brief

General satisfaction level: 7.18/10 Learn more

Treatment's effectiveness: 7.32/10 Learn more

Ease of use: 8.68/10 Learn more

Adherence to prescription: 8.30/10 Learn more

Detected side effects: 5.29/10 Learn more

Improvement in the quality of life: 7.71/10 Learn more

1 = Not at all satisfied
10 = Extremely satisfied

1 = Not at all satisfied
10 = Extremely satisfied

1 = Not at all satisfied
10 = Extremely satisfied

1 = Never
10 = Always

1 = Not at all important
10 = Extremely important

1 = Not at all satisfied
10 = Extremely satisfied

Tips and advice of the community


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KPangela
on 19/10/2024

Extremely simple to administer with the new Epi pen design.

Been on this drug for many years, it was like when I first took Volatrol, such a transformation in my ability to do things without pain.

Yes there are a few side effects but I have learnt ways of coping with them.


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KPangela
on 19/10/2024

Made so much easier with the new Epi pen design.

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GILL18
on 04/03/2023

Makes me feel really wiped out for a couple of days and I have some headaches, am on biologic with it but still have flare ups

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vashyy
on 08/06/2021

Methotrexate has been great for me, it was the first medication I was put on when I was 21 and I have been able to reduce my dose over the years. I know some people experience nausea but I'm thankful that I have never had this problem.

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Emxalou
on 22/06/2020

This medication helped with my pain And skin, it made me feel comfortable in my skin. 

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Cliogirl123
on 16/05/2020

I've been on 15mg methotrexate for over 20 years, it wipes me out physically for up tov48 hrs, but it has made a tremendous improvement on my RA. I still get Flare ups, I normally end up in hospital.  

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ElkePickard
on 05/04/2020

Methotrexate sent my liver function through the roof over 300, it made me feel awful, I couldnt pinpoint what was wrong all I could say was I felt really poorly. I was taken off it untill my bloods went back to normal, put back on it and the same thing happened.

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Egilps70
on 05/01/2020

I have been using methotrexate for 7 years now. I started on 10mg/week.

In the beginning  I caught every virus/bug going around but this has settled now.

I am now on 15mg/week.

Before using this drug, I was in a lot of pain and could barely walk upstairs or dress myself.

Now I am pain free and living a normal life. Working full time and having an active social life.

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Unregistered member
on 03/10/2019

In the beginning when I first started taking Methotrexate I had niggling ailments like Thrush, Iritis, Ear infections, Chest infections anything that was 'doing the rounds' really.

I have been taking this drug since 2005, and after initial side effects I have no problems with it for the last 10 years or so.

I value it's reaction to my AS. Brilliant, Pain is now under control.

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KPangela
on 03/09/2019

I do not like the brain fog I get with it it makes everything I have to do on a daily basis very difficult

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speedtriple3
on 06/06/2019

Hi All, I have been taking meth-troxate for 5 yrs approx and up till now been on 10 mg /wk 

I am getting some swelling on finger joints and more pain on knees and wrists, all seems

to be happening in the last 3 wks or so is the answer to up the dose , I am at a loss as to what to do.

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Unregistered member
on 07/04/2019

Think Positive and stick at it, I'll come right in the end???

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KPangela
on 25/03/2019

Relax the thigh if injecting there.  Also you can inject in the belly area (that fat roll when you sit down).  For me ints a monthly circle so now i dont bruise as much.

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Shamira
on 21/02/2019

I am taking MTX for about more than a year and it has allowed me to go back to normal life. I started off with 10mg and then increased to 20mg. Its action is slow but pretty steady. There is a lot of fearful information on MTX, and it made me apprehensive about it, but fortunately, I did not have much side effects, except feeling headaches, nausea it the beginning, I also lost quite a bit of hair. Few tips from my experience:

- take it before you go to bed. Obviously, do not take folic acid on that day, or eat a lot of veg and spinach. 

- Eat light food, with a lot of protein from plant sources and simple grains like white rice, rice noodles, rice pasta, buckwheat, quinoa with nonspicy lentil soup. I usually eat congi (mushy rice soup with lentil, chicken and ginger). 

-Drink plenty of water and organic celery juice, if possible with organic ginger and turmeric to support the drug action. These also help to reduce inflammation which will allow you to keep the dose low for a long time. 

- if you throw up, don't panic, it will get better slowly, but try not to stop the MTX. 

- try a brief walk in the neighbourhood every morning, rain or shine. this will keep good blood circulation. 

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Eileens
on 18/02/2019

Makes me feel sick and headachy..like a hangover..constantly have a sore tummy.

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BoxWood2
on 21/01/2019

Has anyone on Methotrexate suffered or is suffering with breathing problems?

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Daisydef
on 01/12/2018

Hair lose including intimate body hair is noticeable I definitely found the metoject pens made me less nauseous than the tablets which made me vomit like I’d never done before 

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Caroline37
on 13/07/2018

I have been in this drug for just over a year and it is a miracle. No pain or swelling etc. Highly recommend 

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Lindayoung
on 09/07/2018

Injection Sometimes drained and sleepy and sickly 

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Lindayoung
on 09/07/2018

Sometimes drained and sleepy and sickly 

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Unregistered member
on 22/06/2018

I have been taking this drug Methotrexate for sum 12 years for my 'Ankilosing Spondulitis Arthritis'. My Immune System was shot to pieces in the beginning but has 'settled down' over time. I still get the 'odd' bout of 'Genital Thrush' or 'Iritis' in one or both eyes needing injections into my eye, painless. Ear Infections lasting a couple of days is another 'niggling' problem.You are susceptible to what ever 'Virus' or 'Germ' that is doing the rounds.

The only concern of late has been that my LIVER was showing signs of 'leakage', so Methotrexate was stopped for two weeks then a blood test and back on the drug. My Consultant Raj Sengupta at 'The Royal Hospital for Rheumatic Diseases' in BATH in North Somerset has been monitoring my condition very closely, and has altered or added medication when he has thought that I would benefit, for nearly 9 years. I'm not complaining. I'm very 'Thankful' to them all at The RNHRD.

'Seek and ye shall find'  There is ALWAYS help out there if you look hard enough and ask if you are not sure about something.

Yeah!! So this 'Methotrexate' is OK for majority of the population. You'll get used to it's funny little ways.

Good Luck!!

Richard. 

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Unregistered member
on 16/06/2018

Don't Give Up...... Stay POSITIVE 

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Members using this Methotrexate

Conditions related to this medication

See the fact sheet
Fact sheet

Breast cancer

See the fact sheet
Fact sheet

Psoriasis

See the fact sheet