Increlex (mecasermin): Reviews and patient testimonials
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Medication indications
Increlex 10mg/ml solution for injection
For the long-term treatment of growth failure in children and adolescents from 2 to 18 years with severe primary insulin-like growth factor-1 deficiency (Primary IGFD).
Severe Primary IGFD is defined by:
• height standard deviation score ≤ –3.0 and
• basal IGF-1 levels below the 2.5th percentile for age and gender and
• GH sufficiency.
• Exclusion of secondary forms of IGF-1 deficiency, such as malnutrition, hypothyroidism, or chronic treatment with pharmacologic doses of anti-inflammatory steroids.
Severe Primary IGFD includes patients with mutations in the GH receptor (GHR), post-GHR signaling pathway, and IGF-1 gene defects; they are not GH deficient, and therefore, they cannot be expected to respond adequately to exogenous GH treatment. It is recommended to confirm the diagnosis by conducting an IGF-1 generation test.
Route of administration: Injectable
Molecule: mecasermin
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