Future technology could make psoriasis pills, injections obsolete

Researchers have developed a novel cell-based strategy for the treatment of psoriasis. Their synthetic biology–based gene circuits “can autonomously couple the detection of disease biomarkers with the production of therapeutic proteins,” according to a study published December 16, 2015 in Science Translational Medicine.   “Implanted designer cells detect the onset of psoriatic flares by measuring the psoriasis-associated proinflammatory cytokines TNF and IL22 in the bloodstream and produce, secrete and systemically deliver the anti-inflammatory cytokines il4 and IL10 which prevents psoriatic flares or cures them. Thus, the cytokine converter converts pro-inflammatory cytokines (TNF and IL22) into anti-inflammatory cytokines (IL4 and IL10),” the study’s senior author Martin Fussenegger, Ph.D., professor of biotechnology and bioengineering, ETH Zurich, in Switzerland, told Dermatology Times.   In a study of mice, the designer cells prevented psoriatic flare onset, stopped acute psoriasis, improved psoriatic skin lesions and restored normal skin-tissue morphology.   If it pans out in humans, the technology could be a game-changer for dermatologists and their psoriasis patients, according to Dr. Fussenegger.   “In the future, dermatologists could implant engineered autologous cells containing the cytokine converter and the implanted device takes full control of the therapy,” Dr. Fussenegger says. “Biologics such as IL4 and IL10 have proven promising in clinical trials, but the half-lives has been found to be too short for an economic therapy. Cell-based in situ production of biopharmaceuticals by implanted designer cells at the right time and dose will expand treatment opportunities of biologics.”   Dr. Fussenegger and colleagues have plans to develop this technology for human clinical trials.   “If successful, we expect this device to go commercial within the next 10 years,” he says.


What do you think about this innovation? What is your current treatment? Do you think this one can work?

Dermatology Times

like so many treatments they use to treat psoriasis there are the side effects on the human system good or bad.  it is alright them coming up with a new drug tested on mice  but until they actually do the human testing on someone who has psoriasis how can they say it will work or not .it is true that biogenetics could be the way forward but only if they were to map the DNA of the individual person to the treatment to reduce the side effects and the body building up an immunity to the treatment over time .

@GildaT 

10 YEARS

This is way to long to wait for this or any other treatments to reach the patient's.

It is about time that 'NICE' ""STOPPED"" considering the COST OF THE TREATMENT, before the WELFARE OF THE PATIENT.

That way MILLIONS of lives could be SAVED or changed for the better.

A classic example of.. BUREAUCRACY OVER LIFE.

Where a group of 'prominent people' get to decide IF 'sick or ill people' can have 'life changing\life saving' medication.

The 'government' are elected into power 'BY THE PEOPLE, TO REPRESENT THE PEOPLE'

NOT

Elected by the people(the majority) to do what is better for THEM(the minority).

It's no wonder that that Britain is NO LONGER 'GREAT BRITAIN'.

It won't be long until Britain becomes 'reliant' on other countries hand outs and support to remain a viable country.

How sad that our once GREAT BRITISH EMPIRE is gradually but constantly disappearing, right before our eyes, yet we fail to see or believe it.

So as the saying goes,

You will reap what you sow.