Rheumatoid Arthritis: Risks and Benefits of Chemotherapy Treatments

I have taken methotrexate for about 7 years now if not longer. I took tablets for years then, injection form into the tops of my legs I couldnt deal with the injections on a weekly basis went back to tablets 8 a week. Makes me feel nauseous everytime I take them, I split the dosage over two nights Friday and Saturday and then feel back to normal for work on Monday. I don't feel like doing anything at the weekend and feel tired etc. About 3 years ago this began not working and I now go to hospital for infusions lasting 6 hours over 2 courses Ritoxamab.  This has greatly helped but it is the next stage up and I still have to take methotrexate. Every person is not the same.  

I've been taking Methotrexate for 8 years now, in conjunction with Humira (adalimumab), and have had no real side affects.  Hair loss was an issue but my specialist suggested increasing the folic acid and splitting the dosage twice weekly which has had a dramatic effect. I agree that tiredness can be an issue but taking my medication at bedtime really helps.

I'm in Ireland and was diagnosed 2 years ago. Was put on methotrexate immediately and was very nauseous for days afterwards.  Then started folic acid to combat the nausea.  I take it for 3 days after methotrexate.  It helps but the tiredness for 24 hours is still bad. I'm now on rituximab infusion twice yearly so with the two RA is under control . 

I have been on methotrexate for many years now and it has gradually increased over the years. I can honestly say that I have had no side effects. I do however take folic acid 6 days a week and also plaquenil. The RA is under control but pain from OA & Fibro so always tired and sleep little. Hope this helps

Hi I was on Methotrexate, had terrible reactions.  I am now on Anti-TNF treatment a lot more powerful upto now fingers crossed the only thing it does, unless its fibro I still get painful flareups but my quality of life is 10% better than what it was.