Amitriptyline (amitriptyline): Reviews and patient testimonials


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Medication indications

Amitriptyline 10mg Film-coated Tablets

Amitriptyline tablets are indicated for:

• the treatment of major depressive disorder in adults

• the treatment of neuropathic pain in adults

• the prophylactic treatment of chronic tension type headache (CTTH) in adults

• the prophylactic treatment of migraine in adults

• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline 10mg Film-Coated Tablets

Amitriptyline is indicated for the treatment of:

- depressive illness, especially when sedation is required

- nocturnal enuresis in children aged 6 years and above when organic pathology has been excluded and no response has been achieved to all other non-drug and drug treatments (used only as third line therapy). Amitriptyline should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline 25mg Film-coated Tablets

Amitriptyline tablets are indicated for:

• the treatment of major depressive disorder in adults

• the treatment of neuropathic pain in adults

• the prophylactic treatment of chronic tension type headache (CTTH) in adults

• the prophylactic treatment of migraine in adults

• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline 25mg Film-Coated Tablets

Amitriptyline is indicated for the treatment of:

- depressive illness, especially when sedation is required

- nocturnal enuresis in children aged 6 years and above when organic pathology has been excluded and no response has been achieved to all other non-drug and drug treatments (used only as third line therapy). Amitriptyline should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline 50mg Film-Coated Tablets

Amitriptyline is indicated for the treatment of:

- depressive illness, especially when sedation is required

- nocturnal enuresis in children aged 6 years and above when organic pathology has been excluded and no response has been achieved to all other non-drug and drug treatments (used only as third line therapy). Amitriptyline should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline Hydrochloride 10mg/5ml Oral Solution

Amitriptyline is indicated for the treatment of:

-Symptoms of depression (especially where sedation is required).

- Nocturnal enuresis in children aged six years and above when organic pathology has been excluded and no response has been achieved to all other non-drug and drug treatments (used only as third line therapy). Amitriptyline should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline hydrochloride 10mg/5ml Oral Solution

Amitriptyline is indicated for:

• the treatment of major depressive disorder in adults

• the treatment of neuropathic pain in adults

• the prophylactic treatment of chronic tension type headache (CTTH) in adults

• the prophylactic treatment of migraine in adults

• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products.

This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline Hydrochloride 25mg/5ml Oral Solution

Amitriptyline is indicated for:

• the treatment of major depressive disorder in adults

• the treatment of neuropathic pain in adults

• the prophylactic treatment of chronic tension type headache (CTTH) in adults

• the prophylactic treatment of migraine in adults

• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline hydrochloride 25mg/5ml Oral Solution

Amitriptyline is indicated for:

• the treatment of major depressive disorder in adults

• the treatment of neuropathic pain in adults

• the prophylactic treatment of chronic tension type headache (CTTH) in adults

• the prophylactic treatment of migraine in adults

• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products.

This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline hydrochloride 50mg/5ml Oral Solution

Amitriptyline is indicated for:

• the treatment of major depressive disorder in adults

• the treatment of neuropathic pain in adults

• the prophylactic treatment of chronic tension type headache (CTTH) in adults

• the prophylactic treatment of migraine in adults

• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products.

This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline Hydrochloride 50mg/5ml Oral Solution

Amitriptyline is indicated for:

• the treatment of major depressive disorder in adults

• the treatment of neuropathic pain in adults

• the prophylactic treatment of chronic tension type headache (CTTH) in adults

• the prophylactic treatment of migraine in adults

• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline Tablets BP 10mg

Amitriptyline is indicated for:

• The treatment of major depressive disorder in adults

• The treatment of neuropathic pain in adults

• The prophylactic treatment of chronic tension type headache (CTTH) in adults

• The prophylactic treatment of migraine in adults

• The treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin- related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline Tablets BP 25mg

Amitriptyline is indicated for:

• The treatment of major depressive disorder in adults

• The treatment of neuropathic pain in adults

• The prophylactic treatment of chronic tension type headache (CTTH) in adults

• The prophylactic treatment of migraine in adults

• The treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin- related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.

Amitriptyline Tablets BP 50mg

Amitriptyline is indicated for:

• The treatment of major depressive disorder in adults

• The treatment of neuropathic pain in adults

• The prophylactic treatment of chronic tension type headache (CTTH) in adults

• The prophylactic treatment of migraine in adults

• The treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin- related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.


Route of administration: Oral
Molecule: amitriptyline

Patients' opinions on Amitriptyline

In brief

General satisfaction level: 5.29/10 Learn more

Treatment's effectiveness: 5.12/10 Learn more

Ease of use: 8.71/10 Learn more

Adherence to prescription: 8.94/10 Learn more

Detected side effects: 5.56/10 Learn more

Improvement in the quality of life: 5.56/10 Learn more

1 = Not at all satisfied
10 = Extremely satisfied

1 = Not at all satisfied
10 = Extremely satisfied

1 = Not at all satisfied
10 = Extremely satisfied

1 = Never
10 = Always

1 = Not at all important
10 = Extremely important

1 = Not at all satisfied
10 = Extremely satisfied

Tips and advice of the community


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Bussb2
on 21/02/2019

This tablet gave me a cotton wool brain and made me feel down and depressed when taking it...


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JosephineO • Community manager
on 10/05/2019

@Bussb2‍  I'm sorry to hear that this medication had negative side effects for you but thank you for sharing your opinion, this helps other members discover and learn about their medication :)

Your message


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weefeemcdee
on 16/04/2019

I take 15mg to get me off to sleep. Often wake at silly o'clock & next morning I find my mouth is so dry that my tongue sticks to the roof of my mouth & insides of my cheeks stick to my teeth, makes talking difficult . Chewing gum helps resalavate my mouth.


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JosephineO • Community manager
on 10/05/2019

@weefeemcdee‍ Thank you for sharing your opinion, this helps other members discover and learn about their medication :)

Your message


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Mandy59
on 10/04/2024

It just doesn’t work for me so l am going to have it taken off my repeat prescription

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Mandy59
on 04/01/2024

I have been prescribed this drug and despite upping the dose several times as my consultant had advised it has been of no use to me at all

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Tigger.co.uk
on 05/10/2023

I used to take 1tablet at night but now I take 2 tablets 25mg it does help me with my ptsd low moods depression and anxiety but I still find it hard to sleep I also take canderstartan as well but this bad sleeping is since I was diagnosed with cancer I have finished all my treatment but I still find it hard to sleep as I am so worried that I will end up with secondaries at the moment I am in remission but the worry is still there plus having so many illnesses it is really worrying, Tigger

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Mandy59
on 17/10/2020

I despair. This medication has no affect on me  at all. It’s useless to me. Didn’t help at all. Was started on 10mg = hopeless. Then 20mg= still no affect. Then 30mg= nothing 40mg= nothing then finally 50mg & was told that was the highest dose they would allow. Absolutely no affect whatsoever. Was prescribed it as a little helper to my other medication  to ease pain & help me sleep. It did neither. 👎

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weefeemcdee
on 03/07/2020

I take Amitriptolene to help me get off to sleep. A side affect is a really dry mouth the morning after. To avoid my tongue sticking to the roof of my mouth I have a piece of chewing gum after breakfast.

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suz1964
on 05/11/2019

Mine was increased to 50mg at bedtime. I get a much better sleep and my pain during the day now has reduced! Yes I get bad dry mouth but well worth it to have a good sleep. Before taking Amitriptyline I would weaken 5-10 times a night!

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Myfibro
on 01/10/2019

Since diagnosed in 2007 I was immediately put on 1x 25mg tablet a night.. Even after all these years I know if I forget then am wide awake through the night till I realise hadn't taken it. So yes I do fall asleep with it but not stay asleep.. But we'll take any bit that helps and this does. 

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Tigger.co.uk
on 08/07/2019

I have tried every medication that the doctor prescribed but I still find it very hard to sleep i take 2 amitriptyline which my doctor uped the dosage it used to be one at night now it is two and one canderstan but I still cant sleep that good it takes me ages to fall asleep and in the day I'm so tired but if I go to bed I am wide awake 

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Mandy59
on 05/07/2019

Doesn’t work for me started at 10mg & after talking to specialist Rheumatology nurse she advised l could go up 10mg weekly till l was taking 50mg a week. Still no difference in presumed pain relief & still no effect in helping with sleep. At next appointment l shall tell her l am no longer willing to take something that does nothing to help me. A complete waste of time for me personally. 

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Tigger.co.uk
on 02/07/2019

I have to take two of these 75mg at night for my anxiety PTSD and low moods depression I have been suffering from this because of all the trauma gone on in my life I have been on lots of other meds but nothing seemed to help so since my breast cancer they have upped my dosage to help me sleep but I still dont be able to sleep straightaway I just take cat naps because of my pain but he cant give me anything else so I he just up them instead 

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Trudij
on 14/04/2019

I'm now on 75mg at night for nerve pain associated with trigeminal neuralgia but also take for fibro and arthritis pain. 

I no longer have side effects 

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Mandy59
on 09/04/2019

This medication does not work for me at all when prescribed at 10mg.          So after letting hospital know there’s no marked difference in my sleep pattern or it’s evidence of dulling pain due to my arthritis they prescribed 20mg. Still no effect. I think this dosage is useless so will inform health professionals l don’t want it at such a minuscule dose. I took it for several months & noticed no change whatsoever. 

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Mandy59
on 28/03/2019

As l was only prescribed 10 mg yet again it has been no use whatsoever in helping me sleep & no noticeable asset to easing pain. Been prescribed this on numerous occasions  & in my opinion it’s rubbish.

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Roy's​boy
on 29/10/2018

I take one tablet a night sleep about one hour then restless all night 

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Hazeld
on 30/06/2018

I take three of these three hours before I go to bed. I have terrible problems getting to sleep because of the pain i am in and the doctor thought these would help. They certainly help me get off to sleep but about an hour and a half later I'm awake again.

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Members using this Amitriptyline

Conditions related to this medication

Fact sheet

Depression

See the fact sheet